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KMID : 0829220140380050247
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Korean Journal of Oral and Maxillofacial Pathology
2014 Volume.38 No. 5 p.247 ~ p.256
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Cinnamaldehyde Derivative, 2'-benzoyloxycinnamaldehyde (BCA), Induces Apoptosis and Autophagy in Human Oral Squamous Carcinoma YD-10B Cells
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김현우:Kim Hyun-Woo
김수아:Kim Soo-A/권성민:Kwon Seong-Min/윤정훈:Yoon Jung-Hoon/이주용:Lee Joo-Young/안상건:Ahn Sang-Gun
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Abstract
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Cinnamaldehyde is known to have the antitumor effects in vitro and in vivo. In this study, we showed a potent and irreversible cytotoxic activity of the Cinnamaldehyde derivative 2'-benzoyloxycinnamaldehyde (BCA) in human Squamous oral cell carcinoma cell, YD-10B. BCA induced YD-10B cell apoptosis in a dose-responsive manner. BCA-induced apoptosis was associated with corresponding increases in a series of key components in the mitochondria-mediated apoptosis pathways, followed by caspase cleavage and PARP activation. We also observed that BCA induced autophagy through Akt/mTOR pathway in YD-10B cells. BCA treatment increased LC3B-II expression, and induced the formation of autophagosomes and autophagic vacuoles. These experimental findings suggest that BCA is a potent inhibitor of cell proliferation in YD-10B cells and provide new insights about leading to the possible development of a new therapeutic agent.
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KEYWORD
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2'-benzoyloxycinnamaldehyde, Oral cancer cell, Cell cycle, Apoptosis, Autophagy
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